Insights by ClawBio Founder - Dr. Manuel Corpas | Ep. 16
Dr. Manuel Corpas — Genomics Researcher & ClawBio Founder
Dr. Manuel Corpas on agentic genomics: AI agents that plan and run genomic analyses on their own, where they can be trusted, and why AI amplifies the gaps in biomedical knowledge.
Key Takeaways
Agents now run whole analyses
Agentic genomics means AI agents that plan, execute and refine multi-step genomic work, choosing tools and handling errors as they go. 14:07
Trust follows ground truth
Agents do well where a right answer exists to benchmark against, as in pharmacogenomics, and worse where interpretation is open. 26:04
AI amplifies what it is built on
Across the nine models he benchmarked, hallucination rose for the diseases the literature neglects. 38:29
Equity has to be designed in
Encoding population-specific differences into an agent's skills made the gaps between ancestries disappear in his tests. 39:30
99% correct is not enough
Clinical use needs results that can be broken into steps and audited, traced and reproduced. 44:53
“The bottleneck is not intelligence anymore. It's your ability to ask questions.”
Chapters
- 0:00Intro1 min
- 0:48Getting into bioinformatics in 20004 min
- 5:07Sequencing his own genome4 min
- 8:47What agentic tools changed5 min
- 14:08What agentic genomics means3 min
- 16:38The Claude Code moment4 min
- 20:46Winning gold at Imperial4 min
- 24:48Where agents excel5 min
- 29:18ClawBio by the numbers3 min
- 31:49AI amplifies everything7 min
- 38:30Designing equity in5 min
- 43:35Why 99% is not enough5 min
- 48:33Running agents around the clock8 min
- 56:44Not superintelligence5 min
